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Hydrogen-Rich Water Generator Benefits Studies 

Sttreatment /cancer therapy

Hydrogen-rich water and Cancer Treatment (Cancer drugs and Chemotherapy)
Hydrogen-rich water and Cancer Treatment (Cancer drugs and Chemotherapy)   This article aims to simplify the implications of the effects of hydrogen-rich water on cancer patients based on the scientific studies cited below.  For full research findings and data, please refer to the actual studies cited. Research Title: Molecular hydrogen alleviates nephrotoxicity induced by an anti-cancer drug Cisplatin without compromising anti-tumor activity in mice.   Researchers: Naomi Nakashima-Kamimura • Takashi Mori • Ikuroh Ohsawa • Sadamitsu Asoh • Shigeo Ohta Source: http://image.sciencenet.cn/olddata/kexue.com.cn/upload/blog/file/2009/2/200921110207718697.pdf Readers are recommended to read the original research papers first for background information and reference links provided to understand more of the scientific terms used in these research studies. The study by Naomi Nakashima-Kamimura • Takashi Mori • Ikuroh Ohsawa • Sadamitsu Asoh • Shigeo Ohta, cited above aims to understand how hydrogen water can reduce or mitigate the negative sides effects of  Cisplatin, a widely used anti-cancer drug in the treatment of a wide range of tumors.  One question that a lay person may want to ask is why conduct a research on hydrogen water and cancer drug, why the link between hydrogen water and a cancer drug is significant? To appreciate this, one needs to know about Cisplatin.  What is Cisplatin? Cisplatin is a chemotherapy drug.  It is used to treat various types of cancers, including sarcomas, breasts, some carcinomas (e.g. small cell lung cancer, and ovarian cancer), lymphomas, and germ cell tumors. (Source: http://en.wikipedia.org/wiki/Cisplatin).  Like all chemotherapy drugs, they have side effects. Cisplatin side-effects include Nephrotoxicity (kidney damage), Neurotoxicity (nerve damage), hearing loss, nausea and vomiting and others.. (Source: http://en.wikipedia.org/wiki/Cisplatin).  Now, why cancer drugs like Cisplatin has negative side-effects and to some extent the drug itself may turn life-threatening. Why a treatment to a disease can turn into a threat?  This is because, Cisplatin causes the accumulation of reactive oxygen species (ROS). What is ROS? Reactive oxygen species (ROS) are chemically reactive molecules containing oxygen. Examples include oxygen ions and peroxides. ROS formation is the result of a natural byproduct of the normal metabolism of oxygen.  But when ROS levels  increase dramatically, these molecules can cause damage to cell structures. This process is known as oxidative stress.  When the cell structure is damaged, the DNA will be damaged and cells may die or mutate and become abnormal. (Source: http://en.wikipedia.org/wiki/Reactive_oxygen_species). In short, ROS cause damages to cell structures or oxidative stress. In simple terms, when cell structures are damaged, cells will also be damaged eventually and the physical well being of a living being is also threatened. This means that while a cancer drug like Cisplatin is effective in killing bad cancer cells, it also caused harm to other cells in your body through oxidative stress. Hence, the question is how do you prevent good cells in your body from being killed while the cancer drug is doing its job to kill the cancer cells? The answer is to introduce antioxidants as protection to reduce the oxidative stress to the other good cells in your body. The Role of Antioxidant An antioxidant is a molecule that inhibits the oxidation of other molecules. Some of the common antioxidants are Vitamin C, Vitamin E, uric acid etc. Antioxidants can also be found in certain food like green tea, oranges, cranberries, blueberries and also the popular herb, Lingzhi. Now, the problem with some of these antioxidants is that some of them are found to interfere with the intended function of the cancer drug. For example, while Cisplatin is good for its anti-tumor effect and prevents the growth of the cancer cells,  the presence of a certain antioxidants  may reduce the anti-tumor killing function of Cisplatin and makes the cancer treatment less effective. Hence, the  trick may be to discover which antioxidant does not disrupt the function of the cancer drug used but yet it is playing the role of an antioxidant by protecting other cells in the body. Unfortunately, it seems up to today, there is no clear conclusion on which antioxidant may be the best to consume. For this reason, some doctors may caution cancer patients that while on cancer therapy such as chemotherapy or  radiotherapy, they are to refrain from taking antioxidants but only resumes when therapy stops. One example is that of Lingzhi which has been found to be a good antioxidant and has anti-cancer effect.  However, one of the side effects of Lingzhi is that it prevents the formation of blood clots which causes open wounds to bleed. Hence, if there is any internal bleeding inside the body of a cancer patient, it can be hard to stop so, it can cause harm than good though it has anti-cancer effect. Hence, some people may recommend Lingzhi when patients are not on a particular cancer treatment. So, what may be a good antioxidant for a cancer patient? What is the meaning of ‘good’ when referring to an antioxidant? The meaning of good based on this study seems to suggest that: a) It does not interfere with the cancer treatment drug function b) It plays the role of an antioxidant to protect good cells with no other negative side-effects to the human body. c) It is safe to consume at higher dosage d) It is easy to administer the antioxidant to the patient at affordable costs and in a practical way. The study by Naomi Nakashima-Kamimura • Takashi Mori • Ikuroh Ohsawa • Sadamitsu Asoh • Shigeo Ohta,  has found that hydrogen with its antioxidant properties has an advantage to protect cells within a safe dosage and it does not disrupt the intended function of the cancer drug,  Cisplatin. In addition to the antioxidant properties, consuming excessive hydrogen does not cause negative effects because when too much hydrogen is taken in, the excess would be expired via the lung. While the study used various ways to administer hydrogen into the subjects tested, such as inhalation of hydrogen gas and consuming hydrogen-rich water, it was found that drinking hydrogen-rich water as a method of delivering the hydrogen needed for its antioxidant effect helps to suppress oxidative stress significantly on the subjects studied. . Now, the researchers concluded that since the results showed that drinking hydrogen-rich water reduces the effect of oxidation stress caused by the cancer drug, then it may suggest that drinking hydrogen- rich water has the potential to improve the patient’s response to the chemotherapy. Furthermore, the researchers concluded that if the negative side effects of the cancer drug can be minimised, then it is expected that with hydrogen would allow higher doses of Cisplatin to be given to patients since hydrogen can efficiently mitigating the negative side-effects. In this study, it should be noted that hydrogen was not the cure for cancer or a form of treatment for cancer. But, hydrogen water may play the role in increasing the chance of recovery for a cancer patient undergoing treatment using Cisplatin as the negative side effects of the drug is reduced. It should be noted that the subjects under study were rats and not human cancer patients. Now, a logical idea derived from here is that if hydrogen-rich water works on Cisplatin as a cancer drug, would it work for other cancer drugs or cancer treatments that may cause oxidative stress? The clue for an answer may be found in the second study below. Title of the Study: Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Researchers: Ki-Mun Kang, Young-Nam Kang, Ihil-Bong Choi, Yeunhwa Gu, Tomohiro Kawamura, Yoshiya Toyoda and Atsunori Nakao. Abstract Background Cancer patients receiving radiotherapy often experience fatigue and impaired quality of life (QOL). Many side effects of radiotherapy are believed to be associated with increased oxidative stress and inflammation due to the generation of reactive oxygen species during radiotherapy. Hydrogen can be administered as a therapeutic medical gas, has antioxidant properties, and reduces inflammation in tissues. This study examined whether hydrogen treatment, in the form of hydrogen-supplemented water, improved QOL in patients receiving radiotherapy. Methods A randomized, placebo-controlled study was performed to evaluate the effects of drinking hydrogen-rich water on 49 patients receiving radiotherapy for malignant liver tumors. Hydrogen-rich water was produced by placing a metallic magnesium stick into drinking water (final hydrogen concentration; 0.55~0.65 mM). The Korean version of the European Organization for Research and Treatment of Cancer's QLQ-C30 instrument was used to evaluate global health status and QOL. The concentration of derivatives of reactive oxidative metabolites and biological antioxidant power in the peripheral blood were assessed. Results The consumption of hydrogen-rich water for 6 weeks reduced reactive oxygen metabolites in the blood and maintained blood oxidation potential. QOL scores during radiotherapy were significantly improved in patients treated with hydrogen-rich water compared to patients receiving placebo water. There was no difference in tumor response to radiotherapy between the two groups. Conclusions Daily consumption of hydrogen-rich water is a potentially novel, therapeutic strategy for improving QOL after radiation exposure. Consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects. (Source: http://www.medicalgasresearch.com/content/1/1/11) Hydrogen-rich Water and Radiotherapy Treatment for Cancer Now, the second study is interesting because the previous study was done on rats while this study is done on 49 human cancer patients.  Instead of using a cancer drug, this study is done on patients receiving radiotherapy treatment for cancer. The researchers of this second study concluded that consumption of hydrogen-rich water reduces the biological reaction to radiation-induced oxidative stress without compromising anti-tumor effects. How Much Hydrogen-rich water to drink? The other question that most people may want to know is, if hydrogen-rich water is beneficial, then how much of the water should be consumed? Perhaps, one can take a cue from the second study on the 49 cancer patients cited earlier (Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors). . In this study: “Subjects were provided with four 500 mL bottles of drinking water per day and instructed to place two magnesium sticks in each bottle of water at the end of each day in preparation for consumption the following day. Participants were asked to drink 200-300 mL from one bottle each morning, and 100-200 mL every a few hours from the remaining three bottles. The subjects were expected to consume 100-300 mL of hydrogen-rich water more than 10 times per day for a total minimum consumption of 1500 mL (1.5 L) and a maximum consumption of 2000 mL (2.0 L). “ From this study, it may suggest that an effective dosage of hydrogen-rich water may be up to 2000ml per day. The frequency of drinking is about 300ml in the morning and 100-300ml every few hours. With hydrogen-rich water makers manufactured for consumers, the drinking 2 litres a day is now possible and more efficient as hydrogen-rich water can now be produced in just 30 minutes. The research mentioned above uses magnesium sticks place in a bottle of water which requires preparation overnight to ensure the water generates enough hydrogen in the water.
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